Role of infection in the death of children with acute lymphoblastic leukaemia.

Overview the Causes of Early Deaths and Advance Supportive Care in Children with Acute Lymphoblastic Leukemia: A Systematic Review

Introduction: The objective of this study is to determine the major causes of early death in acute lymphoblastic leukemia (ALL).  Methods: The following databases including PubMed, EMBASE, Science Direct and Google Scholar were searched for following terms: “acute lymphoblastic leukemia”, “early mortality”, “early death “ and “death in induction phase “. Inclusion criteria were all studies abo...

FACTORS EFFECTIVE IN THE PROGNOSIS OF NEUTROPENIC FEVER IN THE CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Background & Aims: Febrile Neutropenia (FN) is one of the common complications of chemotherapy in the children with malignancy. In this study, we investigated the effective factors in response to the treatment of patients with febrile neutropenia. By using these factors, it is possible to have a better analysis about the severity of infection of these patients and it will helpful in choosing th...

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Pneumothorax and Acute Kidney Injury in the Early Phase of Acute Lymphoblastic Leukemia Induction Therapy due to Aspergillus Fumigatus and Pneumocystis Jirovecii Co-Infection: A Case Report

Leukemia is the most common malignancy in children which leads to immunosuppression and predisposes patients to opportunistic infections. We report a 12-year-old girl with acute lymphoblastic leukemia (ALL) who developed simultaneous infection with pneumocystis Jirovecii pneumonia and aspergillosis in the induction phase of chemotherapy. The patient developed pulmonary cavitation and pneumothor...